Virtualization Forensics: How different is it?

Since coming out with VMware vSphere and Virtual Infrastructure Security: Securing the Virtual Environment, I have continued to consider aspects of Digital Forensics and how current methodologies would be impacted by the cloud. My use case for this is 40,000 VMs with 512 Servers and roughly 1000 tenants. What I would consider a medium size fully functioning cloud built upon virtualization technology where the environment is agile. The cloud would furthermore contain roughly 64TBs of disk across multiple storage technologies and 48TBs of memory. Now if you do not think this exists today, you were not at VMworld 2009, where such a monster was the datacenter for the entire show and existed just as you came down the escalators to the keynote session.