End User Computing: Using just a Tablet

Recently I have been trying to lighten my conference going load. To do that, I have been thinking about ways to do without my laptop and all the accessories for it, which got me thinking about what it takes to completely use such a device; to fully embrace the next generation of end-user computing using gesture computing and smaller devices. Other than the technical hurdles, there are also training hurdles as full tablet computing, today, has some serious limitations with respect to security, functionality, and in some ways capability. So how does one embrace tablet computing as their next-gen end user computing?